RESUMO O surgimento do HIV impactou os serviços de saúde abruptamente em 1981, inicialmente afetando grupos sociais restritos. Atualmente, com o desenvolvimento da terapia antirretroviral, nos deparamos com uma doença diferente da encarada na década de 80, agora com uma evolução crônica. Todavia, algumas barreiras permanecem as mesmas, como o impacto social, mental e físico do diagnóstico na vida da pessoa que vive com HIV. O objetivo do presente estudo é verificar carga viral, contagem de linfócitos CD4+, e qualidade de vida de pessoas que vivem com o vírus da imunodeficiência humana. A presente pesquisa trata-se de um estudo observacional transversal com amostra de 24 indivíduos de ambos os sexos, com sorologia positiva para HIV, em acompanhamento médico sob tratamento antirretroviral. Foi utilizado um instrumento próprio para a coleta de informações sociodemográficas. Os resultados de contagem de CD4+ e a Carga Viral do HIV foram coletados dos prontuários médicos dos pacientes. A Qualidade de vida (QV) foi avaliada através do WHOQOL-HIV-BREF. Foi utilizada a análise descritiva para a caracterização do perfil da amostra. Os participantes (46,8± 9,2 anos) possuem ensino médio completo (41,8%), com renda de um a três salários mínimos (37,5%). Apresentam de um a três anos de diagnóstico e contagem de linfócitos CD4 acima de 500 mm3 de sangue (75%). Em relação à QV, os participantes apresentaram média mais alta para o domínio físico (26,7± 5,3) e mais baixa para os domínios de meio ambiente (10,9± 2,7) e relações sociais (12,2± 2,8). O estudo conclui que as pessoas que vivem com HIV participantes do estudo são adultos jovens, com renda e nível de escolaridade baixas, apresentam baixa qualidade de vida em relação aos domínios meio ambiente e relações sociais.

ABSTRACT The emergence of HIV abruptly impacted health services in 1981, initially affecting restricted social groups. Currently, with the development of antiretroviral therapy, we are faced with a different disease from the one seen in the 80s, now with a chronic evolution. However, some barriers remain the same, such as the social, mental and physical impact of the diagnosis on the life of the person living with HIV. The objective of the present study was to verify the viral load, CD4+ lymphocyte count, and quality of life of people living with the human immunodeficiency virus. This was a cross-sectional observational research with a sample of 24 individuals of both sexes, with positive serology for HIV, in medical follow-up under antiretroviral treatment. A specific instrument was used to collect sociodemographic information. CD4+ count and HIV viral load results were collected from patients’ medical records. Quality of life (QoL) was assessed using the WHOQOL-HIV-BREF. Descriptive analysis was used to characterise the sample profile. Participants (46.8± 9.2 years) have completed high school (41.8%), with an income of one to three minimum wages (37.5%). They present a three-year diagnosis and CD4 lymphocyte count above 500 mm3 of blood (75%). Regarding QoL, the participants had a higher average for the physical domain (26.7± 5.3) and lower averages for the environment domains (10.9± 2.7) and social relationships (12.2± 2.8). The study concludes that the people living with HIV who participated in the study are young adults, with low income and level of education, with a low quality of life in relation to the environment and social relations domains.

RESUMO Diante da cronificação da infecção pelo HIV, fatores psicossociais surgem como potencializadores para elevação dos níveis de estresse nas PVHIV, bem como para o desequilíbrio imunológico e elevação da carga viral. O objetivo da presente pesquisa foi avaliar o nível de estresse, a contagem de linfócitos TCD4 + e a carga viral de pessoas vivendo com HIV submetidas a TARV, atendidas em um hospital público universitário. Tratou-se de um estudo observacional, transversal com 25 pacientes (40,76 anos± 9,88 anos) que vivem com HIV atendidos no ambulatório de um hospital público do Rio de Janeiro. Foi utilizado um questionário sociodemográfico para caracterização da amostra, o estresse foi avaliado através do Inventário de Sintomas de Stress de LIPP e observados exames laboratoriais recentes. Foi identificado estresse em 68% dos participantes, com predomínio de sintomas físicos e fase de resistência. Houve maior prevalência de estresse em pessoas com baixo nível socioeconômico, desemprego e diagnóstico recente. Não foram observados menores níveis de linfócitos TCD4 + ou maior carga viral nas pessoas com estresse.

ABSTRACT Given the chronicity of HIV infection, psychosocial factors emerge as potentiators for the elevation of stress levels in PLHIV, as well as for the immunological imbalance and elevation of the viral load. The present research objective was to evaluate the stress level, TCD4+ lymphocyte count and viral load of people living with HIV undergoing ART, treated at a public university hospital. This was an observational, cross-sectional research with 25 patients (40.76 years± 9.88 years) living with HIV treated at the outpatient clinic of a public hospital in Rio de Janeiro. A sociodemographic questionnaire was used to characterise the sample. Stress was evaluated through the LIPP Stress Symptom Inventory and observed in recent laboratory tests. Stress was identified in 68% of the participants, with a predominance of physical symptoms and a resistance phase. There was a higher prevalence of stress in people with low socioeconomic status, unemployment and recent diagnosis. Lower levels of CD4+ T lymphocytes or higher viral load were not observed in people with stress.

Abstract Aim: To investigate the hypothesis that the resistance exercise (RE) may be safer if the blood pressure (BP) is properly controlled through antihypertensive pharmacological treatment in hypertensive middle-aged women. Methods: The final sample was comprised of 19 hypertensive women, with an average age of 58±5 years and a body mass index of 29±5 Kg/m2. They were divided into three groups: controlled (n=6), uncompensated (n=8), and untreated (n=5). The subjects from all groups were submitted to a test of maximal strength on extensor chair and held a session of RE (knee extension, 3x12 to 60% 1RM) and the cardiovascular response (BP and heart rate) was monitored continuously by photoplethysmography during exercise and until five minutes after exercise (recovery). Results: Systolic BP (SBP) and diastolic BP (DBP) responses were lower in the controlled group compared to the other groups (p<0.05). The heart rate was not different between groups, while the double product was lower in the controlled group compared to the untreated group (p<0.05). The SBP and DBP peaks were lower in the controlled group compared to the other groups (p<0.05). Conclusion: The BP increases significantly during RE when the hypertension is not controlled. Pharmacological control was shown to be effective in preventing the increase of BP during the performance of the RE.